diff --git a/boards/arm/v2m_musca_s1/CMakeLists.txt b/boards/arm/v2m_musca_s1/CMakeLists.txt
index bbb12938dce..15313d539ab 100644
--- a/boards/arm/v2m_musca_s1/CMakeLists.txt
+++ b/boards/arm/v2m_musca_s1/CMakeLists.txt
@@ -1,8 +1,15 @@
 #
 # Copyright (c) 2019-2020 Linaro Limited
+# Copyright 2026 Arm Limited and/or its affiliates <open-source-office@arm.com>
 #
 # SPDX-License-Identifier: Apache-2.0
 #
 
 zephyr_library()
 zephyr_library_sources(pinmux.c)
+
+if(CONFIG_BUILD_WITH_TFM)
+  set_property(TARGET zephyr_property_target
+    APPEND PROPERTY TFM_CMAKE_OPTIONS -DCRYPTO_HW_ACCELERATOR=OFF
+    )
+endif()